Prevalence of Various Sign and Symptoms of Diabetic Peripheral Neuropathy


  • Kahkshan Asif Department of Physiology, University of Karachi, Karachi, Pakistan
  • Qurat ul ain Department of Physiology, University of Karachi, Karachi, Pakistan



Diabetes, Diabetic neuropathy, Hyperglycemia, Diabetic Peripheral Neuropathy, Foot infection, DPN.


BACKGROUND: Diabetes mellitus (DM) is a chronic metabolic syndrome marked by hyperglycemia due to absolute or relative deficiency of insulin hormone. Diabetic neuropathy is a complication of both type 1 and type 2 diabetes. Although pain is one of the most dominant symptoms of diabetic neuropathy, its pathophysiological mechanisms yet unknown. Toxic effects of high glucose levels play an important role in the development of this complication.

METHODOLOGY: Data was collected through the questionnaire regarding Clinical findings, medical records, weight, age, family history, different habits, and psychogenic behavior. All the patients with the mentioned diseases are included in this study, excluding the mentally ill patients and the pregnant women.

RESULT:  The result of the present study showed that diabetic neuropathy is the most common complication of diabetes mellitus. It has been observed that most of the patients due to lack of awareness are suspected to the elevated or extreme blood sugar level which leads to neuropathy. Due to the Diabetic Peripheral Neuropathy (DPN) most of the patients suffering from foot problems, foot ulcers and then amputations. Lack of awareness, lack of health management, obesity, blood pressure changes, less care plays a key role in increasing the chances of diabetic neuropathy. COCLUSION: Diabetic neuropathy had very bad influence on a person’s health and daily activities. The Patient education programs need to emphasize on large scale. The ultimate aim of this study is the foot care education for people with the diabetes and to prevent foot ulcers and amputation.


Boulton A. Management of Diabetic Peripheral Neuropathy. Clinical Diabetes. 2005; 23(1):9-15.

Callaghan B, Gao L, Li Y, Zhou X, Reynolds E, Banerjee M et al. Diabetes and obesity are the main metabolic drivers of peripheral neuropathy. Annals of Clinical and Translational Neurology. 2018; 5(4):397-405.

Davies M, Brophy S, Williams R, Taylor A. The Prevalence, Severity, and Impact of Painful Diabetic Peripheral Neuropathy in Type 2 Diabetes. Diabetes Care. 2006; 29(7):1518-1522.

Årsand E, Bradway M, Gabarron E. What Are Diabetes Patients Versus Health Care Personnel Discussing on Social Media?. Journal of Diabetes Science and Technology. 2019; 13(2):198-205.

Faselis C, Katsimardou A, Imprialos K, Deligkaris P, Kallistratos M, Dimitriadis K. Microvascular Complications of Type 2 Diabetes Mellitus. Current Vascular Pharmacology. 2020; 18(2):117-124.

Ishibashi F, Kosaka A, Tavakoli M. The Impact of Glycemic Control on Retinal Photoreceptor Layers and Retinal Pigment Epithelium in Patients with Type 2 Diabetes without Diabetic Retinopathy: A Follow-Up Study. Frontiers in Endocrinology. 2021; 12.

Majumder A, Chatterjee S, Maji D. Peripheral neuropathy in diabetes. J Indian Med Assoc. 2013 Jun; 111(6):382, 384-6. PMID: 24761495.

McNeely M, Boyko E, Ahroni J, Stensel V, Reiber G, Smith D et al. The Independent Contributions of Diabetic Neuropathy and Yasculopatny in Foot Ulceration: How great are the risks. Diabetes Care. 1995; 18(2):216-219.

Ponirakis G, Petropoulos I, Alam U, Ferdousi M, Asghar O, Marshall A et al. Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes. American Journal of Hypertension. 2019; 32(8):796-803.

O'Brien S, Schwedler M, Kerstein M. PERIPHERAL NEUROPATHIES IN DIABETES. Surgical Clinics of North America. 1998; 78(3):393-408.

Tesfaye S, Boulton A, Dyck P, Freeman R, Horowitz M, Kempler P et al. Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments. Diabetes Care. 2010; 33(10):2285-2293.

Thomas P. Classification, Differential Diagnosis, and Staging of Diabetic Peripheral Neuropathy. Diabetes. 1997; 46(Supplement_2):S54-S57.

Vinik A, Casellini C, Parson H, Colberg S, Nevoret M. Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events. Frontiers in Neuroscience. 2018; 12:591.




How to Cite

Asif, K., & Qurat ul ain. (2021). Prevalence of Various Sign and Symptoms of Diabetic Peripheral Neuropathy. BioSight, 2(1), 24–30.



Original Article