Bacteriological profile and antimicrobial susceptibility patterns of symptomatic bloodstream infection in Dhaka City

Authors

  • Abedin Zakerin Dept. of Microbiology, School of Biomedical Science, KhwajaYunus Ali University, Bangladesh
  • Md. SifatUz Zaman Dept. of Microbiology, Popular Diagnostic Centre, Dhaka, Bangladesh
  • Fayez Ahmed Dept. of Microbiology, Popular Diagnostic Centre, Dhaka, Bangladesh
  • Farida Yeasmin Faculty of Basic Medical and Pharmaceutical Science, University of Science and Technology Chittagong
  • Md. Babul Aktar Dept. of Microbiology, School of Biomedical Science, KhwajaYunus Ali University, Bangladesh
  • Rasheda Yasmin Shilpi Laboratory of Microbiology, Department of Botany, Jahangirnagar University, Savar, Bangladesh
  • Abdullah Akhtar Ahmed Dept. of Microbiology, School of Biomedical Science, KhwajaYunus Ali University, Bangladesh

DOI:

https://doi.org/10.46568/bios.v2i1.25

Keywords:

Bacterial isolates, bloodstream infection (BSI), Septicemia, antibiotic sensitive and resistance patterns

Abstract

INTRODUCTION: Bacteremia, is regarded as a significant reason in all over the world for morbidity and mortality in mainly sick patients. Invasion by microorganisms in blood constitutes the critical issues in infectious disease. The aims and objectives are to find out the pathogenic agents infecting males and females in blood of different age groups and naturally used antimicrobial sensitivity profiles. METHODS: All the blood samples were collected aseptically and tested in Popular Diagnostic Centre, Dhaka, Bangladesh between May, 2020 and October, 2020. Total 305 blood specimens from both sexes of different age groups were collected. Cultural analysis was performed by Gram staining, phenotypic examination, biochemical and serological analysis. Finally, antibiotic susceptibility test was done against commonly used antibiotics. RESULTS: 96 (31.47%) samples yielded a positive culture with predominant isolate being Salmonella typhi (41.66%)  though Salmonella spp., Salmonella typhi, Staphylococcus spp and Pseudomonas spp. were also detected. Like most of previous reports, Salmonella spp was predominant, this corroborates this study. But the profile of antimicrobial susceptibility of the detected organisms varied comparing studies which were done in the past. The isolates were found mostly resistant to nalidixic acid. Most of the pathogens showed tremendous susceptibility against ceftriaxone, cefixime, ceftazidime etc.

CONCLUSION: The antibiotic selection for the treatment of bacteraemia in patients should always be serious concern due to multidrug resistant (MRD) bacterial isolates. For proper treatment of anti-bacterial resistance and critical mortality and morbidity should be related with the sickness. For validating more reliability, this research requires further work.

References

Vasudeva N, Nirwan PS, Shrivastava P. Bloodstream infections and antimicrobial sensitivity patterns in a tertiary care hospital of India. TherAdv Infect Dis 2016; 3: 119–27.

Forbes BA, Sahm DF, Weissfeld AS. Bailey and Scott’s Diagnostic Microbiology. 11th ed. St. Luise Mosby 2002.

Assad Am, Quresh MA, Hasan SM. Clinical significance of coagulase negative Staphylococcus clinical isolates from nosocomial bloodstream infections. Journal Infectious Diseases 2015: 48(5), 356-360.

Reisner BS, Woods GL. Times to detection of bacteria and yeast in 9240 Blood culture bottles. J ClinMicrobiol 1999; 37: 2024-6.

Abedin MZ, Yeasmin F, Faruque MO et al. Enumeration of the antimicrobial susceptibility patterns of different bacterial isolates from ENT patients with ear infections. Eur. J. Med. Health Sci.2020: 2(4), 68-73. https://doi.org/10.34104/ejmhs.020.068073

Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing. Twenty-second informational supplement. Wayne, PA, USA. CLSI 2015.

Abedin, M.Z.,Aktar MB , Zaman MSUet al. Occurrence and Antimicrobial Susceptibility Profiling of Bacteria Isolated from Cultured Pangas Catfish (Pangasiuspangasius) and Climbing Perch (Anabas testudineus) Fishes. J Marine BiolAquacult. 2020: 6(1): 7-12. https://doi.org/10.15436/2381-0750.20.2743

Iqbal H, Mahboob N, Ahmed M, Mamun KZ, Rahim A, Azad KA. Bacteriological profile and antimicrobial susceptibility patterns of blood culture isolates among febrile patients in a Tertiary care hospital, Bangladesh. Journal of Dhaka Medical College. 2018; 27(2):114-22.

Abedin MZ,Jarin L, Rahman MR, Islam R. (2020).Culture positivism exploitation through automated fluorescent-sensor technology from patients with blood stream 10infections. J AdvBiotechnolExpTher. 2020; 3(3): 165-170. https://doi.org/10.5455/jabet.2020.d122

Abedin MZ, Faruque MO, Sifat Uz Zaman M, Nasim R, Hasan R, Jarin L, Islam R, Uddin ME (2020). Prevalence and In Vitro Antibiogram Patterns of Urinary Tract Pathogens in Rural Hospitals in Bangladesh. JCBPS; Section B; May 2020–July 2020, Vol. 10, No. 3; 401-409. doi: 10.24214/jcbps.b.10.3.40109.

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Published

2021-06-30

How to Cite

Zakerin, A., Md. SifatUz Zaman, Fayez Ahmed, Farida Yeasmin, Md. Babul Aktar, Rasheda Yasmin Shilpi, & Abdullah Akhtar Ahmed. (2021). Bacteriological profile and antimicrobial susceptibility patterns of symptomatic bloodstream infection in Dhaka City. BioSight, 2(1), 13–17. https://doi.org/10.46568/bios.v2i1.25

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Original Article