Effect of Ocimum sanctum (Basil) leaf in high-fat-diet induced hyperlipidemic rat


  • Mufzala Shamim Department of Physiology, University of Karachi, Karachi
  • Nazish Iqbal Khan Department of Physiology, University of Karachi, Karachi
  • Zohra Khan Department of Physiology, University of Karachi, Karachi




Hyperlipidemia, high fat diet, cardioprotective, Ocimum sanctum


Dyslipidemia mediated atherosclerosis is the key pathogenesis of several cardiovascular diseases. Present study aimed to evaluate the therapeutic potential of Ocimum sanctum leaf consumption against high-fat-diet induced hyperlipidemia in rat model.

A total of 18 Wistar albino rats (200-215 g) were randomly divided as control, HFD (hyperlipidemic) and OS-treated groups. HFD-group received high fat diet (HFD) for 15 days, OS-treated group administered with Ocimum sanctum leaf powder (200 mg / kg of bodyweight / day) together with HFD diet for 15 days. Blood samples were analyzed for changes in plasma total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and very-low-density lipoprotein. Plasma atherogenic index was also calculated.

HFD administration significantly increase plasma lipid levels and atherogenic index in HFD-group. Ocimum sanctum supplementation significantly reduce decrease plasma total cholesterol, triglyceride, lipoproteins and atherogenic index in OS-treated rats. 

15 days Ocimum sanctum leaf (powder) supplementation at dose of 200 mg / kg of bodyweight / day effectively attenuates dyslipidemia in hyperlipidemic rats.


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How to Cite

Shamim, M., Nazish Iqbal Khan, & Zohra Khan. (2022). Effect of Ocimum sanctum (Basil) leaf in high-fat-diet induced hyperlipidemic rat. BioSight, 3(1), 16–20. https://doi.org/10.46568/bios.v3i1.39



Original Article