Effect of Ocimum sanctum (Basil) leaf in high-fat-diet induced hyperlipidemic rat
Keywords:Hyperlipidemia, high fat diet, cardioprotective, Ocimum sanctum
Dyslipidemia mediated atherosclerosis is the key pathogenesis of several cardiovascular diseases. Present study aimed to evaluate the therapeutic potential of Ocimum sanctum leaf consumption against high-fat-diet induced hyperlipidemia in rat model.
A total of 18 Wistar albino rats (200-215 g) were randomly divided as control, HFD (hyperlipidemic) and OS-treated groups. HFD-group received high fat diet (HFD) for 15 days, OS-treated group administered with Ocimum sanctum leaf powder (200 mg / kg of bodyweight / day) together with HFD diet for 15 days. Blood samples were analyzed for changes in plasma total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and very-low-density lipoprotein. Plasma atherogenic index was also calculated.
HFD administration significantly increase plasma lipid levels and atherogenic index in HFD-group. Ocimum sanctum supplementation significantly reduce decrease plasma total cholesterol, triglyceride, lipoproteins and atherogenic index in OS-treated rats.
15 days Ocimum sanctum leaf (powder) supplementation at dose of 200 mg / kg of bodyweight / day effectively attenuates dyslipidemia in hyperlipidemic rats.
Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Annals of translational medicine. 2016;4(13).
Clifton PM. Diet, exercise and weight loss and dyslipidaemia. Pathology. 2019;51(2):222–226.
Kotecha T, Rakhit RD. Acute coronary syndromes. Clinical medicine (London). 2016;16(6):p. s43–48.
Singh RB, Mengi SA, Xu YJ, Arneja AS, Dhalla NS. Pathogenesis of atherosclerosis: A multifactorial process. Experimental & Clinical Cardiology. 2002;7(1):40-53.
Venkateshan S, Subramaniyan V, Chinnasamy V, Chandiran S. Anti-oxidant and anti-hyperlipidemic activity of Hemidesmus indicus in rats fed with high-fat diet. Avicenna journal of phytomedicine. 2016;6(5):516-525.
Prakash A, Ebenezer AJ, Vasanth S, Nagarajan G, Elden BT. Effect of Ocimum tenuiflorum Linn Extract on Histamine Mediated Allergic Inflammation in Human Mast Cells. Journal of Biologically Active Products from Nature. 2017;7(1):10-7.
Suanarunsawat T, Boonnak T, Ayutthaya WN, Thirawarapan S. Anti-hyperlipidemic and cardioprotective effects of Ocimum sanctum L. fixed oil in rats fed a high fat diet. Journal of Basic and Clinical Physiology and Pharmacology. 2010;21(4):387-400.
Council NR. Guide for the care and use of laboratory animals: National Academies Press; Washington. 2011;220 p.
Shamim M, Naseem E, Khan NI. Hypolipidemic effects of Trigonella foenum-graecum (fenugreek) seed powder administration in rabbits with experimental dietary hyperlipidemia. FUUAST Journal of Biology. 2016;6(1):33-9.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry. 1972;18(6):499–502.
Bairaktari ET, Seferiadis KI, Elisaf MS. Evaluation of Methods for the Measurement of Low-Density Lipoprotein Cholesterol. Journal of Cardiovascular Pharmacology and Therapeutics. 2005;10(1):45–54.
Bo MS, Cheah WL, Lwin S, Moe Nwe T, Win TT, Aung M. Understanding the relationship between atherogenic index of plasma and cardiovascular disease risk factors among staff of an University in Malaysia. Journal of nutrition and metabolism. 2018;2018.
Manjunath CN, Rawal JR, Irani PM, Madhu K. Atherogenic dyslipidemia. Indian Journal of Endocrinology and Metabolism. 2013;17(6):969–76.
Rachmawati NA, Wasita B, Kartikasari LR. Basil leaves (Ocimum sanctum linn.) Extract decreases total cholesterol levels in hypercholesterolemia sprague dawley rats model. In: IOP Conference Series: Materials Science and Engineering [Internet]. Institute of Physics Publishing. 2019;546(6): p. 062020.
Rachmawati E, Muhammad RF. The ethanolic extract of holy basil leaves (Ocimum sanctum L.) attenuates atherosclerosis in high fat diet fed rabbit. In: AIP Conference Proceedings [Internet]. AIP Publishing LLC. 2021;2353(1): p. 030113.
How to Cite
Copyright (c) 2022 BioSight
This work is licensed under a Creative Commons Attribution 4.0 International License.