Genetic Variations of Brain Derived Neurotropic Factor Gene With Premenstrual Syndrome Among Pakistani Menarcheal Girls: A Pilot Study

Authors

  • Mehir un Nisa Iqbal Department of Physiology, University of Karachi
  • Fatima Noor Department of Physiology
  • Taseer Khan Department of Physiology

Abstract

The premenstrual syndrome (PMS) comprises various physical and emotional symptoms which are associated with the menstrual cycle. The emotional changes might be due to the variation in the levels of BDNF especially lower levels of plasma BDNF may be present at the luteal phase of menstrual cycle. To date, no data were present to associate the link between BDNF gene polymorphism and PMS among young Menarcheal females. So, the goal of this investigation is to find out the possible relationship between BDNF gene polymorphism and PMS among young Menarcheal females of Pakistan. A total of 92 menarcheal girls with age range of 11-14yrs met the inclusion criteria. All participants were screened for the depression and PMS using Zung’s depression scale/ Diagnostic and Statistical Manual of Mental Disorders-IV (DSM IV) criteria and world health organization (WHO) criteria for PMS respectively. Genomic DNA was extracted from oral samples by Salting out method and BDNF genotyping was done using PCR-RFLP analysis. Results showed no significant association (χ2=1.685, p-value=0.431) was observed between BDNF genotyping and PMS among menarcheal girls. BDNF (rs6265) AA and GA genotypes did not show significant association with the risk of PMS. Hence, it was concluded that BDNF gene polymorphism may not be associated with the PMS among Pakistani Menarcheal girls

Author Biography

Taseer Khan, Department of Physiology

Associate Professor

Department of Physiology 

University of Karachi

References

Halbreich U, Borenstein J, Pearlstein T, Kahn LS. The prevalence, impairment, impact, and burden of premenstrual dysphoric disorder (PMS/PMDD). Psychoneuroendocrinology 2003; 28 Suppl 3: 1-23.

Hofmeister S, Bodden S. Premenstrual Syndrome and Premenstrual Dysphoric Disorder. Am Family Physician 2016; 94(3): 236-40.

Tolossa FW, Bekele ML. Prevalence, impacts and medical managements of premenstrual syndrome among female students: cross-sectional study in College of Health Sciences, Mekelle University, Mekelle, northern Ethiopia. BMC women's health 2014; 14: 52.

Garg P, Matreja PS, Khosla PP, Kaur L, Mohan P. Correlation of symptoms of premenstrual syndrome in Indian set-up. Am J Health Res 2014; 2(3): 102-5.

Direkvand-Moghadam A, Sayehmiri K, Delpisheh A, Kaikhavandi S. Epidemiology of Premenstrual Syndrome (PMS)-A systematic review and meta-analysis study. J Clin Diagnostic Res 2014; 8(2): 106.

Tabassum S, Afridi B, Aman Z, Tabassum W, Durrani R. Premenstrual syndrome: Frequency and severity in young college girls. Anxiety 2005; 45(27): 4-5.

Dennerstein L, Lehert P, Heinemann K. Global study of women's experiences of premenstrual symptoms and their effects on daily life. Menopause Int 2011; 17(3): 88-95.

Bertone-Johnson ER, Hankinson SE, Forger NG, Powers SI, Willett WC, Johnson SR, et al. Plasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study. BMC women's health 2014; 14(1): 56.

Oral E, Ozcan H, Kirkan T, Askin S, Gulec M, Aydin N. Luteal serum BDNF and HSP70 levels in women with premenstrual dysphoric disorder. Eur Arch Psychiat Clin Neurosci 2013; 263(8): 685-93.

Cubeddu A, Bucci F, Giannini A, Russo M, Daino D, Russo N, et al. Brain-derived neurotrophic factor plasma variation during the different phases of the menstrual cycle in women with premenstrual syndrome. Psychoneuroendocrinology 2011; 36(4): 523-30.

Merlio J-P, Ernfors P, Jaber M, Persson H. Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience 1992; 51(3): 513-32.

Bath KG, Lee FS. Variant BDNF (Val66Met) impact on brain structure and function. Cognitive Affective Behav Neurosci 2006; 6(1): 79-85.

Aguilera M, Arias B, Wichers M, Barrantes-Vidal N, Moya J, Villa H, et al. Early adversity and 5-HTT/BDNF genes: new evidence of gene–environment interactions on depressive symptoms in a general population. Psychol Med 2009; 39(9): 1425-32.

Hosang GM, Shiles C, Tansey KE, McGuffin P, Uher R. Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. BMC medicine 2014; 12(1): 7.

Lau JY, Goldman D, Buzas B, Hodgkinson C, Leibenluft E, Nelson E, et al. BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage 2010; 53(3): 952-61.

Gillings MR. Were there evolutionary advantages to premenstrual syndrome? Evolutionary applications 2014; 7(8): 897-904.

Zung WW. A self-rating depression scale. Arch Gen Psychiatry 1965; 12(1): 63-70.

Wu JQ, Tan YL, Tan SP, Hui L, Lv MH, Soares JC, et al. Altered BDNF is correlated to cognition impairment in schizophrenia patients with tardive dyskinesia. Psychopharmacology 2015; 232(1): 223-32.

Gujral S, Manuck SB, Ferrell RE, Flory JD, Erickson KI. The BDNF Val66Met polymorphism does not moderate the effect of self-reported physical activity on depressive symptoms in midlife. Psychiatry Res 2014; 218(1-2): 93-7.

Pei Y, Smith AK, Wang Y, Pan Y, Yang J, Chen Q, et al. The brain‐derived neurotrophic‐factor (BDNF) val66met polymorphism is associated with geriatric depression: A meta‐analysis. Am J Med Genetics Part B: Neuropsychiatric Genet 2012; 159(5): 560-6.

Downloads

Published

2020-12-31

How to Cite

Iqbal, M. un N., Noor, F., & Khan, T. (2020). Genetic Variations of Brain Derived Neurotropic Factor Gene With Premenstrual Syndrome Among Pakistani Menarcheal Girls: A Pilot Study. BioSight, 1(2), 11–15. Retrieved from https://biosight.org/index.php/bios/article/view/7

Issue

Section

Original Article