Role of Serum Lipid and Apolipoprotein Ratios in Prediction of Diabetic Retinopathy


  • Numan Majeed Department of Chemical Pathology, Army Medical College, Rawalpindi, Pakistan
  • Tariq Mahmood Ahmad Department of Chemical Pathology, Army Medical College, Rawalpindi, Pakistan
  • Asma Hayat Department of Chemical Pathology, Army Medical College, Rawalpindi, Pakistan
  • Sadia Israr Department of Chemical Pathology, Army Medical College, Rawalpindi, Pakistan
  • Amna Saddique Department of Chemical Pathology, Army Medical College, Rawalpindi, Pakistan
  • Safina Shabbir Department of Medicine, Pakistan Navy Station Shifa, Karachi, Pakistan



Diabetic Retinopathy, Lipid ratios, Apolipoproteins


Aims: The objective of the study was to determine clinical utility of different ratios of serum lipid and apolipoprotein as predictive markers for diabetic retinopathy (DR). Methodology: In this case control study, study participants were divided in to four groups, normal controls, diabetic controls, non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). Staging was done based on fundoscopy by an ophthalmologist. A fasting venous blood was assayed for Lipid profile, levels of ApoA1 and ApoB and different combination of ratios for these tests were used to assess association with DR. Results: Independently, only ApoB levels proved to be predictive of DR, but being non-specific to DR it cannot be used as independent marker. Amongst various ratios, only ratios of apolipoproteins were significantly associated with DR. Conclusion: ApoB/ApoA1 ratio is the most suited ratio for screening of DR.


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How to Cite

Majeed, N., Tariq Mahmood Ahmad, Asma Hayat, Sadia Israr, Amna Saddique, & Safina Shabbir. (2023). Role of Serum Lipid and Apolipoprotein Ratios in Prediction of Diabetic Retinopathy. BioSight, 4(1), 3–10.



Original Article