The Association Of Socioeconomic Status With Preeclampsia In Pakistani Females
Keywords:Preeclampsia, Socioeconomic status, Standard of living index
Introduction: To identify whether there is an association between maternal socioeconomic status as in living style, and preeclampsia in women from Pakistan, and if so, to what extent it increases the risk of developing preeclampsia.
Methods: This is a case-control study, consisting of 74 normal pregnant and 76 already diagnosed preeclamptic Pakistani females, recruited from various hospitals in Karachi. Their socioeconomic status was assessed through the standard of living index (SLI) using the National Family Health Surveys (NFHS) criteria, which considers different living facilities as an indicator of socioeconomic status. Odds ratios of preeclampsia were calculated for low, middle and high socioeconomic status and other maternal anthropometric parameters.
Results: Based on their groups, it appeared that the highest percentage of preeclamptic females (n= 65; 43.3%) and the lowest of control patients (n=14; 9.3%) lie in lower socioeconomic groups and the results were highly significantly different. Study observed that having lower socioeconomic status (P<0.001) significantly increase risk of having preeclampsia by 9% and middle socioeconomic status has no role in prevalence of preeclampsia shown by 0.0 odds ratio. In addition, odds ratio of age and PreBMI for the preeclamptic females were found as 1.37 (P<0.001) and 1.55 (P<0.001) respectively, which shows that each year increase in age, increases risk of preeclampsia by 1.37 times and 1.55 times with each increased in BMI.
Conclusion: Living facilities are indications of socioeconomic status and are strong risk factors of preeclampsia
Ghulmiyyah, L., Sibai, B. aternal mortality from preeclampsia/eclampsia. Seminars Perinatol, 2011; 36 (1): 56-59.
Firoz, T, Sanghvi, H, Merialdi, M. Pre-eclampsia in low- and middle-income countries. Best Pract Res Clin Obstet Gynaecol, 2011; 25 (4): 537-548.
American College of Obstetricians and Gynecologists, Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013; 122: 1122–31.
Hofmeyr, R., Matjilab, M., Dyer, R. Obstetric and Anaesthesia Management. Best Practice & Research Clinical Anaesthesiology. 2016; 31(1): 125-13.
Tranquilli, A. L., Dekker, G., Magee, L. (2014). The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Pregnancy Hypertens.2014; 4(2): 97-104.
Ahmed A, Rezai H, Broadway-Stringer S. Evidence-Based Revised View of the Pathophysiology of Preeclampsia. Adv Exp Med Biol. 2017; 956:355-374. doi: 10.1007/5584_2016_168. PMID: 27873232.
Khalil, G., Hameed, A. Preeclampsia: Pathophysiology and the Maternal-Fetal Risk. J Hypertens Manag.2017; 3; 024-30. doi.org/10.23937/2474-3690/1510024
Sava, R. I., Keith, L., Pepine, C. J. Hypertension in pregnancy: Taking cues from pathophysiology for clinical practice. Clinical Cardiology. 2018; 41: 220–227.
Gathiram, P. and Moodley, J. Pre-eclampsia: its pathogenesis and pathophysiolgy. Cardiovasc J Afr.2016; 27(2): 71–78.
Alasztics, B, Kukor, Z, Panczel, Z, Valent, S. The pathophysiology of preeclampsia in view of the two-stage model. Orv Hetil 2012; 153: 1167-1176.
Cox, B. Bioinformatic approach to the genetics of preeclampsia. Obstet Gynecol, . 2014:124, 633.
Easter, S.R., Cantonwine, D.E., Zera, C.A., Lim, K.H., Parry, S.I. Urinary tract infection during pregnancy, angiogenic factor profiles, and risk of preeclampsia. Am J Obstet Gynecol. 2017; 214: e1-e7.
Pare, E., Parry, S., McElrath, T. F., Pucci, D., Newton, A. Clinical risk factors for preeclampsia in the 21st century. Obstet Gynecol. 2014; 124: 763-770.
(Abalos et al., 2013).
Khidri, F. F., Waryah, Y. M., Ali, F. K. MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study. BMC Med Genet 20.2019; 163-168.
Omani-Samani, R., Ranjbaran, M., Amini, P., Esmailzadeh, A., Sepidarkish, M., Almasi-Hashiani, A. Adverse maternal and neonatal outcomes in women with preeclampsia in Iran, The Journal of Maternal-Fetal & Neonatal Medicine.2019; 32(2): 212-216.
Muniyandi, M., Ramachandran, R., Gopi, P. G., Chandrasekaran, V., Subramani, R., Sadacharam, K., Kumaran, P., Santha, T., Wares, F., Narayanan, P.R. (2007). The prevalence of tuberculosis in different economic strata: a community survey from South India. Int J Tuberc Lung Dis. 2007; 11(9):1042-5.
Mrema, D., Lie, R.T., Mahande, M.J., Daltve, A.K. (2018). The association between pre pregnancy body mass index and risk of preeclampsia: a registry based study from Tanzania BMC. Pregnancy Childbirth. 2018; 18: 56-61.
Savitri, A. I., Zuithoff P., Browne J. L., Amelia D., Baharuddin M., Grobbee D. E. and Uiterwaal C. S. P. M. Does pre-pregnancy BMI determine blood pressure during pregnancy? A prospective cohort study.2016; 6(8): e011626.
Jeyabalan, A. Epidemiology of preeclampsia: impact of obesity. Nutrition Reviews; 2013; 71(1): S18–S25.
Mol, B. W., Roberts, C.T., Thangaratinam S. (2016). Preeclampsia. Lancet. PubMed. 2016; 387(10022):999–1011.
Henderson, J.T., Thompson, J.H., Burda, B.U., Cantor, A., Beil, T., Whitlock E.P. Screening for Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force. Agency for Healthcare Research and Quality. 2017; Report No: 14-05211-EF-1
Kumar, P. L., Nirmala, T., Vani, B. R., Srinivasa, M. V., Geetha, R. L. Study of coagulation profile in pregnancy induced hypertension (PIH). Indian J Pathol Oncol. 2015; 2(1): 1-6.
Dong, L., Yanyan, Z., Yi, B., Xijing, L., Yunhui, G., Bin, Z., Lin, Z., Linli, L., Rong, Z. Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women. Chinese medical journal.2014; 127: 2048-52. 10.3760/cma.j.issn.0366-6999.20133337.
Gupta, A., Bindu, S. G., Mishra, K. B., Dubey, I., Gupta, A. et al. A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy. International Journal of Research in Medical Sciences. 2018; 6(2): 671-676.
Priyadarshini, G. P., Mohanty, R. R. Assessment of coagulation profile and its correlation with severity of preeclampsia in women of odisha-a comparative cross-sectional study. Inter J Basic Applied Physiol, 2014; 3(1): 234-240
Haelterman E, Qvist R, Barlow P, Alexander S. Social deprivation and poor access to care as risk factors for severe preeclampsia. Eur J Obstet Gynecol Reprod Biol 2003; 111: 25–32.
Lawlor DA, Morton SM, Nitsch D, Leon DA. Association between childhood and adulthood socioeconomic position and pregnancy induced hypertension: results from the Aberdeen children of the 1950s cohort study. J Epidemiol Community Health 2005; 59:49–55.
Parazzini F, Bortolus R, Chatenoud L, Restelli S, Ricci E, Marozio L, Benedetto C. Risk factors for pregnancy-induced hypertension in women at high risk for the condition. Italian study of aspirin in pregnancy group. Epidemiology 1996; 7:306–308.
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