Powdery Mildew A Disease of Grapes And The Fungicides Mode of Action: A Review

Authors

  • Mueen Uddin Department of Plant Pathology, Lasbela University of Agriculture, Water and Marine Sciences, Uthal Lasbela, Balochistan, Pakistan
  • Juma Khan Tareen Agriculture Research Institute (ARI), Sariab Quetta, Balochistan-Pakistan
  • Faheem Ahmed Agriculture Research Institute (ARI), Sariab Quetta, Balochistan-Pakistan
  • Faisal Adnan Agriculture Research Institute (ARI), Sariab Quetta, Balochistan-Pakistan
  • Mohammad Jafar Bazai Agriculture Research Institute (ARI), Sariab Quetta, Balochistan-Pakistan
  • Syed Rehan Fareed Agriculture Research Institute (ARI), Sariab Quetta, Balochistan-Pakistan
  • Hidayatullah Kakar Agriculture Research Institute (ARI), Sariab Quetta, Balochistan-Pakistan

DOI:

https://doi.org/10.46568/bios.v3i2.78

Keywords:

Grapes, powdery mildew, fungicides, mode of action

Abstract

Powdery mildew caused by Uncinula necator (Schw.) Burr. is one of the widespread fungal diseases of grapes that have caused economic losses through poor fruit set and low yield substantially. To decrease the inoculum potential, a disease management program must be undertaken early in the season which is imperative to reduce late-season disease problems. Because, without early control of the infection of powdery mildew, often lead to severe problem in the late season. Elemental sulfur was the foremost antifungal utilized for the control of powdery mildew which is still in use as an effective and cheap fungicide for vineyards. Sterolbiosynthesis inhibitors (SI), also called SI fungicides, are the latest products to control powdery mildew effectively. For efficient use of fungicides with no or less resistance to the pathogen, it is appropriate to spray fungicides having different mechanisms of action which are specific in function, and for more efficacy, use a mixture of such fungicides that have no harmful impact on plant growth and environment. So, for effective control of powdery mildew, a protective spray of fungicide before bloom and a subsequent spray of systemic fungicides at the time of berry formation ensure healthy and higher grapes yield. This paper reviewed the powdery mildew infection in grapevines and its effect on yield losses with details of fungicides’ mechanism of action and newly developed fungicides having broad spectrum activities.

References

Govt. of Pakistan. Agric. Statistics of Pakistan 2017-18. Pakistan Bureau of Statistics House, 21-Mauve Area, G-9/1, Islamabad, Pakistan 2018.

Khair SM, Ahmad M. Ehsanullah. Profitability analysis of grapes orchards in Pishin: An expost analysis. Sarhad J Agric 2009; 25(1): 103-111.

Poudel PR, Mochioka R, Fujita Y. Growth characteristics of shoots and roots of wild grapes native to Japan. J ASEV Jpn 2010; 21: 8-12.

Sônego OR, Garrido LR, Grigoletti JA. Fungal diseases. In: Grape for processing- Phytosanity. Embrapa Technological Information, (Frutas do Brasil 35) Brasília 2003; pp 11-14.

Tessmann DJ, Vida JB, Genta W, Kishino AY. Doenças e seu manejo. In: Kishino AY, Carvalho SLC, Roberto SR (Org.). Tropical viticulture – the production system of Paraná. Londoner. IAPAR 2007; p.25-293.

Pearson RC, Gadoury DM. Grape Powdery Mildew. In: Kumar J, Chaube HS, Singh US, Mukhopadhyay AN (eds). Plant Diseases of International Importance, Vol. 3 Diseases of Fruit Crops, pp 129-146. Prentice Hall, Englewood Cliffs, NJ, USA 1992.

Stark-Urnau M, Kast WK. Development of ontogenetic resistance of powdery mildew in fruit of differently susceptible grapevines (cvs. Trollinger and Lemberger). Mitt Klosterneuburg 1999; 49: 186-9.

Gadoury DM, Seem RC, Ficke A, Wilcox WF. On- to genetic resistance to powdery mildew in grape berries. Phytopathology 2003; 93: 541-55.

Sadek ME, Shabana YM, Sayed-Ahmed K, Abou Tabl AH. Antifungal Activities of Sulfur and Copper Nanoparticles against Cucumber Postharvest Diseases Caused by Botrytis cinerea and Sclerotinia sclerotiorum. J. Fungi 2022; 8: 412. https: //doi.org/10.3390/ jof8040412

Pearson RC, Goheen AC eds. Compendium of Grape Diseases. St Paul, MN, USA: APS Press. 1988.

Ough CS, Berg HX. Powdery mildew sensory effect on the wine. Am J Enol Vitic. 1979; 30: 321.

Pool RM, Pearson RC, Welser MJ, Lasko AN, Seem RC. Influence of powdery mildew on yield and growth of rosette grapevines. Plant Dis. 1984; 68: 590-3.

Lakso AM, Pratt C, Pearson RC, Pool RM, Welser MJ. Photosynthesis, transpiration, and water use efficiency of mature grape leave infected with Uncinula necator (powdery mildew). Phytopathology 1982; 72: 232-6.

Pool RM, Pearson RC, Welser MJ, Lasko AN, Seem RC. Influence of powdery mildew on yield and growth of rosette grapevines. Plant Dis 1984; 68: 590-3.

Wilcox MH, Gerding DN, Poxton IR, Kelly C, Nathan R, Birch T, et al. Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection. N Engl J Med 2017; 376(4): 305-17.

Bettiga LJ. Comparison of bilateral cordon training methods in the development and productivity of Chardonnay and Point noir grapevines. Proc 20th Int Meet Group Int Exp Vitivinicultureal Sys Cooperation 2017; 20: 576-81.

Chellemi DO, Marois JJ. Influence of leaf removal, fungicide applications, and fruit maturity on incidence and severity of grape powdery mildew. Am J Enol Vitic 1992; 43: 53-7.

Grove GG, Boal RJ, Bennett LH. Managing powdery mildew of cherry in Washington orchards and nurseries with spray oils. Online. Plant Health Progress 2000. doi: 10.1094/PHP-2000-0728-01-RS.

Thomas MR, Matsumoto S, Cain P, Scott NS. Repetitive DNA of grapevine-classes present and sequences suitable for cultivar identification. Theor. Appl. Genet. 1993; 86: 173-80.

Gubler DJ, Trent DW. Emergence of epidemic dengue/ dengue hemorrhagic fever as a public health problem in the Americas. Infect Agents Dis 1994; 2: 383-93.

Ypema M, Pema HL, Gubler WD. Sensitivity of Uncinula necator to benomyl, triadimefon, myclobutanil, and fenarimol in California. Plant Dis 1997; 81: 293-7.

Gubler WD, Ypema HL, Ouimette DG, Bettiga LJ. Occurrence of resistance in Uncinula necator to triadimefon, myclobutanil, and fenarimol in California grapevines. Plant Dis 1996; 80: 902-9.

Steva H. Evaluation of anti-resistance strategies for control of Uncinu/a necator, pp. 59-66. In Proceedings, Fungicide Resistance Conference. 28-30 March 1994, BCPC, Reading, UK. BCPC Monogr. 1994; 60.

Aubert C, Baumes R, Gunata Z, Lepoutre JP, Cooper JF, Bayonove C. Effect of sterol biosynthesis inhibiting fungicides on the aroma of grape. Sci Aliments 1998; 18: 41-58.

Reuveni M, Reuveni R. Efficacy of foliar sprays of phosphates in controlling powdery mildews in field-grown nectarine, mango trees and grapevines. Crop Prot 1995; 14(4): 311-4.

Sawant SD, Sawant IS, Shetty DI, Shinde MA, Jade SA, Waghmare MO. Control of powdery mildew in vineyards by Milastin K, a commercial formulation of Bacillus subtilis (KTBS). J Biol Control 2011; 25: 26-32.

Deliere L, Miclot AS, Sauris P, Rey P, Calonnec A. Efficacy of fungicides with various modes of action in controlling the early stages of an Erysiphe necator-induced epidemic. Pest Manag Sci 2010; 66: 1367-73. DOI 10.1002/ps.2029

Kast WK, Bleyer K. Efficacy of sprays applied against powdery mildew (Erysiphe necator) during a critical period for infections of clusters of grapevines (Vitis vinifera). J Plant Pathol 2011; 1: S29-32.

Cacaj I, Bakir K, Hajdari A, Shala N. The efficacy of spraying programs and treatment methods against downy mildew in two grapevine cultivars in Kosovo. Arch Phytopathol Plant Prot 2014; 47(4): 407-16. doi: 10.1080/03235408.2013.811025

Feng X, Nita M, Anton BB. Evaluation of Quinoxyfen resistance of Erysiphe necator (Grape Powdery Mildew) in a single Virginia vineyard. Plant Dis 2018; 102: 2586-91.

Reddy GR, Kumari AD, Vijaya D. Management of powdery mildew in grape. Plant Arch 2017; 17(1): 651-4.

Souza RTD, Naves RDL, Conceição MAF, Costa SMD, Savini TC. Frequency of fungicide application for controlling downy mildew in seedless grape plant ‘BRS Vitória’. Rev Bras Frutic 2018.

Hewitt G. New modes of action of fungicides. Pestic. Outlook 2000; 11(1): 28-32.

Yang H, Tong J, Lee CW, Ha S, Eom SH, Im YJ. Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2. Nat Commun 2015; 6: 6129.

Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. Molecular biology of the cell. London: Garland Publishing, Inc 2002.

Iwaki T, Iefuji H, Hiraga Y, Hosomi A, Morita T, Giga-Hama Y, Takegawa K. Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe. Microbiology 2008; 154: 830-41.

Hewitt G. New modes of action of fungicides. Pestic Outlook 2000; 11(1): 28-32.

Fishel FM. Pesticide toxicity profile: Neonicotinoid pesticides. IFAS, University of Florida 2005.

Mueller D, Bradley CA, Nielsen J. Field crop fungicides for the North Central United States. Ames: Agricultural Experiment Station, Iowa State University 2008.

Vagi P, Preininger E, Kovacs GM, Kristof Z, Boka K, Böddi B. Structure of plants and fungi (pp. 1–109). Eötvös Loránd University, Budapest 2013.

Radzuhn B, Lyr H. On the mode of action of the fungicide etridiazole. Pesticide Biochem Physiol 1984; 22: 14-23.

Kawai M, Yamagishi JI. Mechanisms of action of acriflavine: Electron microscopic study of cell wall changes induced in Staphylococcus aureus by acriflavine. Microbiol Immunol 2009; 53: 481-6.

Yoshimi A, Kojima K, Takano Y, Tanaka C. Group III histidine kinase is a positive regulator of Hog1-type mitogen-activated protein kinase in filamentous fungi. Eukaryot Cell 2005; 4: 1820-8.

Yang C, Hamel C, Vujanovic V, Gan Y. Fungicide: Modes of action and possible impact on nontarget microorganisms. ISRN Ecol 2011; ID 130289: 1-8. doi: 10.5402/2011/130289

Tanaka C, Izumitsu K. Two-component signaling system in filamentous fungi and the mode of action of dicarboximide and phenylpyrrole fungicides. In: Carisse O. (Ed.). Fungicides. London: Intech Open 2010 (cited 2022 Nov 25).

Rosslenbroich HJ, Stuebler D. Botrytis cinerea – History of chemical control and novel fungicides for its management. Crop Prot 2000; 19: 557-61.

Kim JH, Campbell BC, Mahoney N, Chan KL, Molyneux RJ, May GS. Enhancement of fludioxonil fungicidal activity by disrupting cellular glutathione homeostasis with 2, 5-dihydroxybenzoic acid. FEMS Microbiol. Lett 2007; 270: 284-90.

Ochiai N, Fujimura M, Oshima M, Motoyama T, Ichiishi A, Yamada-Okabe H, Yamaguchi I. Effects of iprodione and fludioxonil on glycerol synthesis and hyphal development in Candida albicans. Biosci. Biotechnol. Biochem 2002; 66: 2209-15.

Hagiwara D, Matsubayashi Y, Marui J, Furukawa K, Yamashino T, Kanamaru K. et al. Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses. Biosci Biotechnol Biochem 2007; 71: 844-7.

Vargas-Pérez I, Sánchez O, Kawasaki L, Georgellis D, Aguirre J. Response regulators SrrA and SskA are central components of a phosphorelay system involved in stress signal transduction and asexual sporulation in Aspergillus nidulans. Eukaryot. Cell 2007; 6: 1570-83.

Joseph-Horne TIM, Hollomon DW, Wood PM. Fungal respiration: A fusion of standard and alternative components. Biochim Biophys Acta Bioenerg 2001; 1504: 179-95.

Fujii K, Takamura S. Pyricut® (difulmetorim, UBF-002EC) –A new fungicide for ornamental use. Agrochemicals Japan, 1998; 72: 14-15.

Tomlin CDS. The Pesticide Manual, A World Compendium, 14th Edition British Crop Protection Council. Alton Hampshire 2006; 186-7.

Motoba K, Uchida M, Tada E. Mode of antifungal action and selectivity of flutolanil. Agric Biol Chem 1988; 52: 1445-9.

Joseph-Horne TIM, Hollomon DW, Wood PM. Fungal respiration: A fusion of standard and alternative components. Biochim Biophys Acta Bioenerg 2001; 1504: 179-95.

Matsson M, Hederstedt L. The carboxin-binding site on Paracoccus denitrificans succinate: Quinone reductase identified by mutations. J Bioenerg Biomembr 2001; 33: 99-105.

Spiegel J, Stammler G. Baseline sensitivity of Monilinia laxa and M. fructigena to pyraclostrobin and boscalid. J Plant Dis Prot 2006; 113(5): 199-206.

Smith DL, Garrison MC, Hollowell JE, Isleib TG, Shew BB. Evaluation of application timing and efficacy of the fungicides fluazinam and boscalid for control of Sclerotinia blight of peanut. Crop Prot 2008; 27: 823-33.

Gisi U, Sierotzki H, Cook A, McCaffery A. Mechanisms influencing the evolution of resistance to Qo inhibitor fungicides. Pest Manag Sci 2002; 58: 859-67.

Mueller D, Bradley CA, Nielsen J. Field crop fungicides for the North Central United States. Ames: Agricultural Experiment Station, Iowa State University 2008.

Vincelli P. Q I (strobilurin) fungicides: Benefits and risks. Plant Health Instr 2002.

Guo, ZJ, Miyoshi H, Komyoji T, Haga T, Fujita T. Uncoupling activity of a newly developed fungicide, fluazinam [3-chloro-N-(3-chloro-2, 6-dinitro-4-trifluoromethylphenyl) -5-trifluoromethyl-2-pyridinamine]. Biochim Biophys Acta Bioenerg 1991; 1056: 89-92.

Brandt U, Schubert J, Geck P, von Jagow G. Uncoupling activity and physicochemical properties of derivatives of fluazinam. Biochim Biophys Acta Bioenerg 1992; 1101: 41-7.

Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J. (Eds.). Molecular cell biology (4th ed.). New York: W. H. Freeman. ISBN: 2000; 10: 0-7167-3136-3.

Hall RA, Lenardon MD, Alvarez FJ, Nogueira FM, Mukaremera L, Gow NAR. The Candida albicans cell wall: Structure and role in morphogenesis and immune recognition. The Fungal Cell Wall 2013; 1-26.

Halling-Sørensen B, Sengeløv G, Tjørnelund J. Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline resistant bacteria. Arch Environ Contam Toxicol 2002; 42: 263-71.

Carr JF, Gregory ST, Dahlberg AE. The severity of the streptomycin resistance and streptomycin dependence phenotypes of ribosomal protein S12 of Thermus thermophilus depends on the identity of highly conserved amino acid residues. J Bacteriol 2005; 187: 3548-50.

Seiler JP. Toxicology and genetic effects of benzimidazole compounds. Mutat Res Genet Toxicol 1975; 32: 151-67.

McCarroll NE, Protzel A, Ioannou Y, Stack HF, Jackson MA, Waters MD, Dearfield KL. A survey of EPA/OPP and open literature on selected pesticide chemicals: III. Mutagenicity and carcinogenicity of benomyl and carbendazim. Mutat Res Rev Mutat Res 2002; 512: 1-35.

Gupta K, Bishop J, Peck A, Brown J, Wilson L, Panda D. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin. Biochemist 2004; 43: 6645-55.

Koo BS, Park H, Kalme S, Park HY, Han JW, Yeo YS, et al. α-and β-tubulin from Phytophthora capsici KACC 40483: Molecular cloning, biochemical characterization, and antimicrotubule screening. Appl Microbiol Biotechnol 2009; 82: 513-24.

Zhou Y, Xu J, Zhu Y, Duan Y, Zhou M. Mechanism of action of the benzimidazole fungicide on Fusarium graminearum: Interfering with polymerization of monomeric tubulin but not polymerized microtubule. Phytopathology 2016; 106: 807-13.

Rathinasamy K, Panda D. Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells. The FEBS J 2006; 273: 4114-28.

Fisher DJ, Hayes AL. Mode of action of the systemic fungicides furalaxyl, metalaxyl and ofurace. Pestic Sci 1982; 13: 330-9.

Sukul P, Spiteller M. Metalaxyl: Persistence, degradation, metabolism, and analytical methods. Rev Environ Contam Toxicol 2000; 164: 1-26.

Hollomon DW, Chamberlain K. Hydroxy pyrimidine fungicides inhibit adenosine deaminase in barley powdery mildew. Pestic Biochem Phys 1981; 16: 158-69.

Brown JK, Simpson CG. Genetic analysis of DNA fingerprints and virulences in Erysiphe graminis f.sp. hordei. Curr Genet 1994; 26: 172-8.

Iv ˘anescu B, Burlec AF, Crivoi F, Rosu C, Corciov ˘a A. Secondary metabolites from artemisia genus as biopesticides and innovative nano-based application strategies. Molecules 2021; 26: 3061. https: //doi.org/10.3390/ molecules26103061

Chen SK, Edwards CA, Subler S. Effects of the fungicides benomyl, captan and chlorothalonil on soil microbial activity and nitrogen dynamics in laboratory incubations. Soil Biol Biochem 2001; 33: 1971-80.

Cycoń M, Piotrowska-Seget Z, Kozdrój J. Responses of indigenous microorganisms to a fungicidal mixture of mancozeb and dimethomorph added to sandy soils. Int Biodeterior Biodegrad 2010; 64(4): 316-23.

Milenkovski S, Baath E, Lindgren PE, Berglund O. Toxicity of fungicides to natural bacterial communities in wetland water and sediment measured using leucine incorporation and potential denitrification. Ecotoxicol 2010; 19: 285-94.

AgroSciences. Internal market research based on panel data supplied by AgrobaseLogigram. Archamps, France 2008.

Runkle J, Flocks J, Economos J, Dunlop AL. A systematic review of Mancozeb as a reproductive and developmental hazard. Environ. Int 2017; 99: 29-42.

Bartett DW, Clough JM, Godfrey CR, Godwin JR, Hall AA, Heaney SP, Maund SJ. Understanding the strobilurin fungicides. Pestic. Outlook 2001; 12: 143-8.

Bartlett DW, Clough JM, Godwin JR, Hall AA, Hamer M, Parr-Dobrzanski B. The strobilurin fungicides. Pest Manag. Sci 2002; 58: 649-62.

Ishii H, Zhen F, Hu M, Li X, Schnabel G. Efficacy of SDHI fungicides, including benzovindiflupyr, against Colletotrichum species. Pest Manag Sci 2016; 72: 1844-53.

Downloads

Published

2022-12-31

How to Cite

Uddin, M. ., Tareen, J. K. ., Ahmed, F. ., Adnan, F. ., Bazai, M. J. ., Fareed, S. R. ., & Kakar, H. . (2022). Powdery Mildew A Disease of Grapes And The Fungicides Mode of Action: A Review. BioSight, 3(2), 38–52. https://doi.org/10.46568/bios.v3i2.78

Most read articles by the same author(s)

Similar Articles

You may also start an advanced similarity search for this article.