Comparison of hormones levels in response to OGTT between healthy and newly diabetic subjects.
DOI:
https://doi.org/10.46568/bios.v5i2-3-4.175Keywords:
Insulin, Glucagon, GLP-1, GIP, Sensitivity IndexesAbstract
Introduction With an epidemic of diabetes, pathophysiological role of insulin, glucagon and incretin secretion and insulin resistance (IR) can be obtained by intermediate measures to oral glucose tolerance test (OGTT). To compare hormones levels in response to oral glucose tolerance tests and related biochemical parameters between healthy and newly diagnosed diabetics (NDD). Methods This prospective cross-sectional study was conducted at Karachi University-Pakistan with collaboration of Baqai Institute of Diabetology and Endocrinology, Karachi-Pakistan and Kansai Electric Power Medical Research Institute, Osaka-Japan from March 2019 to May 2020. Baseline details were noted on predesigned questionnaire. Blood samples for baseline parameters and hormones were obtained during OGTT. Results Out of 34 participants, 17 were NDD and 17 were healthy subjects. The study found rise in insulin levels at fasting and decreased at 30 and 60minutes in NDD subjects when compared with healthy subjects. It was found that glucagon levels were increased at 30 and 60 minutes, GLP-1 at 0 and 60 minutes in NDD group in comparison to healthy subjects. Higher HOMA IR and lower HOMA-β were observed in the NDD group. Insulin levels were significantly associated with age and RBC in NDD subjects. Moreover, levels of GLP-1 were significantly correlated with cholesterol, LDL, HDL and non-HDL, while GIP with age, LDL and non-HDL in NDD subjects. Conclusion Pattern of insulin, glucagon and incretins levels with HOMA-IR and glucose metabolism sensitivity indexes during an OGTT strongly predict development of T2DM.
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Copyright (c) 2024 Nazish Waris, Samina Bano, Asher Fawwad, M. Hafizur Rahman, Abdul Basit
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